I just got back from a one-week stay in Santo Domingo and want to recommend the Museo del Hombre Dominicano or Museum of the Dominican Man. It is located within Plaza de la Cultura (Cultural Plaza) and it is the best among several museums in the Plaza. The location centers around Maximo Gomez Ave., Bolivar, and Cesar Nicolas Penson Sts. Visiting this museum was the highlight of the trip for me. I would recommend asking one of the guides to take you on a tour if you don't read Spanish.
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