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You have to go from Punta Cana to Higuey, Higuey to La Romana. Take the highway from La Romana to Santo Domingo. There are road signs to Santiago. You generally just go straight on 27 de Febrero.. When you get to the big archway you go to the right. About a mile or so up the Luperon road, past the Herrera Airport, you have to go under the main highway, and loop around to your right, just like in the States or Canada. That highway goes all the way to Santiago. Lots of places to stop along the way.
As you reach Santiago, you will see a big pyramid-style hotel going up on your right. then the Fortaleza and then the new HOMS medical center, all on your right.
there are four traffic lights after the Fortaleza. Be sure to be on the right by the time you reach the fourth one. (There is a Shell station acrosss the road). As you pass the light, stay to the right, the road has a fork, and you bear to the right. Go about 200-300 yards further on and take the fork that bears off to the right--there is a sign that says Puerto Plata. You will see a movie theater HOLLYWOOD 7 on your right as your are turning to the right.
This road is the one that will take you to POP. Just follow it across town, take the elevated portion to miss a couple of lights, and it comes out at the beginning of the Duarte/ Joaquin Balaguer Highway towards Navarrete.
As you pass the big pile of gravel on your right and come to the major intersection of Navarrete, go to the right and follow that road all
the way to Cofres?. Piece of cake.
Hope this helps you. It is a long drive. You will need a lot of RD$5.00 peso pieces to pay the tolls. About RD$40,00 or so...
HB