What is the best way...

Rocky

Honorificabilitudinitatibus
Apr 4, 2002
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SDQ to Caribe tour bus station, then bus it to Barahona.
Maybe 30 bucks for the cab and 10 or less for the bus.
The busses leave at 6:15 9:45 AM and
1:45 5:15 PM.
 

Motorcycler

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Jan 20, 2007
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My wife and I took the 1:45 PM a couple of weeks ago and it will have you in Barahona by 4:15PM. Great ride, very comfortable and quiet. Extremely affordable $6.00US.

Takes about 3 hours on a day where traffic is heavy and about 2.5 when its light.

From Las Americas talk to a taxi or one of the poublicos and settle on a price before heading out to Caribe Tours. I would not pay more than 15-20US. I don't know if a shuttle is available to go into Santo Domingo.