The area you're referring to is a mixed bag, (like pretty much most areas in SD) there are different parts to it, and different demographics within it too. You'd have to be specific about which street/part to get a decent gauge on it. I have some friends who live in a nice area there.
FYI, Republica de Colombia does not run through this area, the street name changes to Jardines de Fontainbleau at the bottom left corner of the park which then runs into JFK at the bottom.