Do You Mean the Colonial Zone in the Capital?
There are several good hotels, like Palacio, Hotel La Condes, a lot to see historically and many eating places and of course the El Conde pedestrian mall with many shops and such. It is a bit of a hike to the malecon, e.g. the Jaragua and Melia hotels but it's all pretty compact and worth at least a day
trip if not a couple of days.
Tip: The "free" tour guides around the old buildings are anything but, and you need to have long pants and no sleevless tops to enter some of the buildings, such as the mausoleum of DR heroes and the eternal flame - the soldiers there will not admit you if not respectuflly dressed.