apparently their sting is the 2nd most painful insect sting in the world, after the Bullet Ant.
Interesting, I thought the Asian Giant Hornet might 1 or 2.
An allergic human stung by the giant hornet may die from an allergic reaction to the venom.
The venom contains a neurotoxin called mandaratoxin (MDTX),[9] a single-chain polypeptide with a molecular weight of approximately 20 kD,[9] which can be lethal even to people who are not allergic if the dose is sufficient. However if the victim is allergic to the sting this means an almost certain death.
I have been stung by N. American wasp (did not hurt much) and ground hornets. Both times with the Hornets I ended up in the hospital, 5/7 stings. Bastards they are