It is possible. In the bus you must pay for the luggages if they are to big and it is not commfortable!!!!!!
I would recommend to rent a car or take a taxi!
It is possible! I have taken luggage on 3 guagas from Santo Domingo to Consuelo. I agree, it is not comfortable at all and a huge pain!!
P.S. Never try to take luggage on a motoconcho! hee, hee..... that doesn't work either.