Thanks for replies so far. PJT, we are in the DR for 2 weeks, and expect to relax at the hotel one day, and take a tour the next day, and so on for the 14 days. As well as Santo Domingo we are thinking of including the following:
Visit to Puerto Plata, including going up the Cable Car to the botanical gardens, visit a rum factory and seeing cigars being made, amber museum.
Sosua and Carbarete for nice beaches and some local shopping
Whale Watching in Samana
Jungle Safari or Monster Jeep tour, whichever seems best
Catamaran trip somewhere - recommendations?
Jarabacoa - just to experience the cool air and waterfalls
I think there's more than enough we'll miss off the schedule to make a return trip again.
We'll think about the club-life but perhaps will reserve that for next time too, we are not big clubbing people really.