Extreme caution should be exercised on the Santo Domingo-Samana highway, if it is that one that you are referring to. Recently, government officer Quilvio Cabrera was killed when his suv crashed into a cow on the road.
Will post here once we get updates on when the road will be safe to drive.
Otherwise, would not recommend anyone who is not experienced on it to drive, and even then, extreme caution should be taken.