1-Taking the road thought Sanfrancisco De Macoris it is 200 kilometers, (3 hours).
2-Going thought La Cumbre Carretera de Jamao Al Norte, mountain road with the prettiest views you’ll ever see, it is 240 kilometers, (4 hours).
3-Driving thought”Puerto Plata city” is more than 300 kilometers this way will take you about 5 hours.
I personally recommend the second one.
JJ