Best route to Santiago
Las Terrenas to Sanchez, Sanchez to Nagua, Nagua to San Francisco, once in San Francisco keep going straight (do not turn right) at the University, then go 1 mile to the Texaco gas station and turn left as if going to Santo Domingo. At the next light turn right (there?s a tire repair shop on your left), go straight and that will take you to a little park, the intersection with the main road going to Autopista Duarte. Turn left as if you?re goint to Santo Domingo. Keep on that NEW road until you hit the main Highway 1 (autopista Duarte), follow right toward Santiago. That route affords you the most time on highway and new roads. The section Nagua to San Francisco is the most curvy one and with the most pot holes as well, but you?ll skip mountains. I?ve done it in 3 hrs or 3.5 hours, but I have a high truck.