Just as easy:
Santo Domingo-> San Francisco de Macor?s-> Tenares-> Salcedo
Basically, Salcedo sits astride the highway that goes from Nagua to Santiago....
You can get there lots of ways.
For example, you could take the new highway (toll road) to Nagua, turn west and get there.
You can go to La Vega, turn North through Las Yerbas and get there.
Nice little town...
HB