La Casona Dorada would be a good choice. Large, offstreet parking area in the complex, rooms air conditioned and there are a pool and restaurant. Not a luxury hotel, but a good, moderately priced one. Located on Avenida Independencia, tel 809-221-3535/476-7910.
Casona Dorada is good value for the money. The staff is friendly and the Hotel is fairly quiet.
They even have a bar/disco which is usually pretty empty but the barmaid and waitresses are fun to talk to.
I originally stayed there because I couldn't get a room anywhere else at the last minute. I have returned there once so far and will stay there again at the end of june.
BTW they also have on site laundry/dry clean and get your clothes back to you in about an hour!
I have stayed there, it was ok but I prefer the Duque De Wellington, right down the stree. About the same price but recently updated, clean, A/C that works, and super friendly staff. A new hotel downtown in the Colonial District recently opened up, the Foreigners Club. Dorothy from the US totally restored and updated a beautiful small hotel, pretty quiet area but close to the historic district, etc. E,ail me if you want further info.
I just stayed at a great hotel in the Colonial Zone called the Caribe Colonial. Small (54 rooms) art deco hotel with very attentive, great staff. Highly recommeded. The rates for a standard room are $65 a night. The have a website www.hodelpa.com, then click on Caribe Colonial.