One Not To Miss item is the Centro Leon. Located on Ave 27 de Febrero in Villa Progreso. This is about 5 minutes from the intersection of Estrella Sadhala and 27 de Febrero. All taxis know it.
Another place is the Ceballos Art Gallery, in Reparto Panorama, just off of Juan Pablo Duarte Ave, about 150 yards past the Ayuntamiento building ...
If you like see how "the other half" lives, go up to Los Cerros De Gurabo and look at the "modest" dwellings of Santiago society.
If you like to watch future baseball players, go down in back of the baseball park and watch the kids play any afternoon.
If you want to see a really Dominican setting, go down to Ave Valerio and walk down to Los Hospedajes, the marketplace where all the fruits and veggies arrive into Santiago. Go in long pants and shoes...
There is also the Morel Folklore Museum on Restauraci?n Street, just down from 30 de Marzo.
Remember, Santiago is not a tourist town and caters more to cultural events: concerts, displays and such at the Teatro Regional up near the Monumento (NOT Monumental!!)...
For night life, I am sure you can get into trouble by yourself...
HB