Almost all pufferfish contain tetrodotoxin, a deadly toxin that is up to 1,200 times more poisonous than cyanide. The poison in one pufferfish is enough to wipe out 30 humans, and there's no known antidote. Yet, many people eat it.
Fugu or puffer fish can be lethally poisonous due to its tetrodotoxin; therefore, it must be carefully prepared to remove toxic parts and to avoid contaminating the meat.
The restaurant preparation of fugu is strictly controlled by law in Japan and several other countries, and only chefs who have qualified after three or more years of rigorous training are allowed to prepare the fish. Domestic preparation occasionally leads to accidental death.
Fugu is served as sashimi and chirinabe. Some consider the liver the tastiest part, but it is also the most poisonous, and serving this organ in restaurants was banned in Japan in 1984. Fugu has become one of the most celebrated and notorious dishes in Japanese cuisine.
So, if you are eating locally prepared puffer fish, you have to ask yourself, "Am I feeling lucky today?"