Since we are talking about clubs now!
Matrix and Metropolis are both in Pointe Orlando(International Drive - also known as I-drive across from the convention center). They are right across from each other in the second floor. If you pay for admission to one you can go back and forth from one to the other the whole night. I like to go on Sundays because it is latin night. They have merengue, salsa, and bachata at Metropolis(mostly salsa and merengue) and reggeaton at Matrix. You will see a more older and sophisticated crowd at Metropolis. They also have pool tables and plush furniture to relax in there. They just started Rhythm nights every thursday at Metropolis with Merengue, salsa, and reggeaton.
In the I-drive area they have another club named Copa that plays salsa, merengue, and bachata. Mostly salsa and most of the people that go there are older (over 25).
At Citywalk Universal they have Latin Quarter. It is a restaurant with a dance floor that converts into a disco at night. I don't really like to go dancing there because too many tourists go there. They go in their shorts and sneakers and they let them in. I like to dress up and go out. The club itself is very nice. It's just that the tourists give it a different atmosphere. I don't know, maybe you will like it. The food is great at Latin Quarter by the way.
In downtown Orlando there are many clubs. They are not strictly latin clubs but they do have latin nights on some nights. I have to research some more on that because Tabu had latin nights on Thursdays and I heard that they changed it.
At the corner of Bennet and Colonial Drive they have a nice club called Roxy's. I love going there. They have two dance floors and three bars. The one in the main floor plays merengue, salsa, and bachata. They have a second floor with another bar that plays reggeaton. They supposedly have a third smaller dance floor when you first enter the club that plays strictly salsa but I never see that many people dancing there anyway. Latin nights at Roxy's is on wednesdays.
On South Orange Blosson Trail (OBT) they have another latin club called Coco Bongos. They have latin music on Thursday, Friday, and Saturday. Saturdays are the best days to go. On most thursdays they usually have bands that come to play live. I have seen La Banda Gorda, Fernandito Villalona, Joe Veras, Kinito Mendez, among others. Aventura is coming soon.
There is also Mirage on S. Oakridge Rd. I like to go there on Saturdays. I only like to go for the music. It's the place that has the most updated music in Orlando.
Like Jon mentioned, El Rancho is out of the way. We went when they had To?o Rosario and Malafe. We don't really like to go because most of us like to drink and we don't like to drive that far. If you have a designated driver I guess it is OK, but in my opinion it's not worth the trip because they don't bring orquestas anymore and it's not what it used to be.
In Downtown Disney they have Pleasure Island. You pay one admission fee and you can enter their seven clubs. None play latin music. at the House of Blues they bring live bands. Mostly American bands but the other day they had Don Omar and Wisin y Yandel.
If I think of anymore, I will let you know.