There have been several studies exploring the potential anticancer properties of ivermectin.
Here are some key findings from recent research:
## Mechanisms of Action
Ivermectin has demonstrated multiple mechanisms that may contribute to its anticancer effects:
1. Inhibition of cell proliferation and induction of apoptosis in various cancer cell types[1][3][4].
2. Modulation of key signaling pathways involved in cancer progression, including Wnt/β-catenin, PI3K/Akt/mTOR, and STAT3[5].
3. Induction of immunogenic cancer cell death and enhancement of T cell infiltration into tumors[2].
4. Promotion of ROS-mediated mitochondrial apoptosis pathway[6]. 5. Inhibition of angiogenesis and metastasis[4].
## Cancer Types Studied
Research has investigated ivermectin's potential against multiple cancer types, including:
- Breast cancer[2][4]
- Colorectal cancer[3][6]
- Ovarian cancer[4]
- Glioblastoma[3]
- Leukemia[3]
- Cholangiocarcinoma[7]
## Notable Findings
- Ivermectin showed synergistic effects when combined with checkpoint inhibitor anti-PD1 antibody in breast cancer models[2].
- It demonstrated potential to overcome drug resistance in some cancer cell lines[3][7].
- Ivermectin exhibited more potent effects against gemcitabine-resistant cholangiocarcinoma cells compared to gemcitabine-sensitive cells[7].
Sources
[1] Ivermectin and Cancer: Exploring the Potential Link
https://williamscancerinstitute.com/ivermectin-and-cancer-exploring-the-potential-link/…
[2] Ivermectin converts cold tumors hot and synergizes with immune ...
https://nature.com/articles/s41523-021-00229-5…
[3] Anti-parasitic Drug Ivermectin Exhibits Potent Anticancer Activity ...
https://ar.iiarjournals.org/content/39/9/4837…
[4] Ivermectin, a potential anticancer drug derived from an antiparasitic ...
https://pmc.ncbi.nlm.nih.gov/articles/PMC7505114/…
[5] The Anticancer Potential of Ivermectin: Mechanisms of Action and ...
https://jlar.rovedar.com/index.php/JLAR/article/view/11…
[6] Ivermectin has New Application in Inhibiting Colorectal Cancer Cell ...
https://frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.717529/full…
[7] Anti-parasitic Drug Ivermectin Exhibits Potent Anticancer Activity ...
https://ar.iiarjournals.org/content/anticanres/39/9/4837.full.pdf